Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over last 50 years. Early detection particularly difficult due to lack disease-specific symptoms and reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) surgery become standard care for patients PDAC. Carbohydrate antigen 19–9 (CA 19–9) common diagnostic biomarker; however, it not specific enough especially asymptomatic patients. Non-coding RNAs are often deregulated in human shown be involved cancer-related mechanisms such as cell growth, differentiation, death. Several micro, long non-coding circular have been reported date Aim this review discuss roles functions diagnosis treatments